Clin Ther 5:398–408Īzuma J, Sawamura A, Awata N, Ohta H, Hamaguchi T, Harada H, Takihara K, Hasegawa H, Yamagami T, Ishiyama T et al (1985) Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial. Int J Cardiol 2:303–304Īzuma J, Hasegawa H, Sawamura A, Awata N, Ogura K, Harada H, Yamamura Y, Kishimoto S (1983) Therapy of congestive heart failure with orally administered taurine. Am J Cardiovasc Dis 1:293–311Īzuma J, Hasegawa H, Sawamura A, Awata N, Harada H, Ogura K, Kishimoto S (1982) Taurine for treatment of congestive heart failure. Neuropharmacology 27:309–318Ībebe W, Mozaffari MS (2011) Role of taurine in the vasculature: an overview of experimental and human studies. Hypertension 10:383–389Ībe M, Tokunaga T, Yamada K, Furukawa T (1988) Gamma-aminobutyric acid and taurine antagonize the central effects of angiotensin II and renin on the intake of water and salt, and on blood pressure in rats. In this review, we summarize the beneficial actions of taurine in CHF, focusing on its antagonism of the catecholamines and angiotensin II.Ībe M, Shibata K, Matsuda T, Furukawa T (1987) Inhibition of hypertension and salt intake by oral taurine treatment in hypertensive rats. Taurine has also attracted attention because it has beneficial actions in CHF, in part by its demonstrated inhibition of the harmful actions of the neurohumoral factors. Both groups of pharmaceutical agents decrease mortality and improve the quality of life, a testament to the critical role of the sympathetic nervous system and the renin-angiotensin system in the development of CHF. In the past decade, angiotensin II blockade and β-adrenergic inhibition have served as the mainstay in the treatment of CHF. There is mounting evidence supporting the utility of taurine as a pharmacological agent against heart disease, including chronic heart failure (CHF). Taurine, a ubiquitous endogenous sulfur-containing amino acid, possesses numerous pharmacological and physiological actions, including antioxidant activity, modulation of calcium homeostasis and antiapoptotic effects.
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